High-throughput experimentation reaction monitoring and analysis of chemistry synthesis products with ultrahigh-throughput 4D timsTOF fleX MALDI-2 technologyMALDI mass spectrometry is uniquely suited...
項目：質(zhì)譜
產(chǎn)品配置：17臺儀器，0個耗材，0個試劑
Elucidation of metabolic changes in HFD-ApoE–/– model by SP6 peptide: A flow injection analysis magnetic resonance mass spectrometry (FIA-MRMS) study Natural peptides have emerged as an attractiv...
樣品：Spirulina Platensis (SP6) 項目：質(zhì)譜
產(chǎn)品配置：28臺儀器，0個耗材，0個試劑
Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annot...
樣品：脂質(zhì) 項目：質(zhì)譜成像
產(chǎn)品配置：16臺儀器，0個耗材，0個試劑
However, the dynamic range of protein concentration in these samples poses a challenge for in-depth proteome quantification. PASEF? is a powerful technology for rapid in-depth and sensitive proteome q...
樣品：血漿 項目：質(zhì)譜
產(chǎn)品配置：17臺儀器，0個耗材，0個試劑
In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted in HEK293 cells overexpressing the transport protein OATP2B1.Estrone-3-Sulfate (E3S)...
樣品：transport protein OATP2B1 項目：質(zhì)譜
產(chǎn)品配置：27臺儀器，0個耗材，0個試劑
MALDI Mass Spectrometry Imaging (MSI) as a versatile and robust tool for analyzing different types of analytes in various samples requires a well-thought-out experiment setup.Here we present a straigh...
樣品：、 項目：質(zhì)譜成像
產(chǎn)品配置：27臺儀器，0個耗材，0個試劑
將具有抗原特異性的 Affimers 共價結(jié)合在 BAMS 磁珠上，再親和捕獲 SARS-CoV-2 上的刺突糖蛋白亞基1（ S1 糖蛋白 ）， 這為 S1 糖蛋白檢測奠定了重要的基礎(chǔ)。將選擇性捕獲的完整 S1 糖蛋白洗脫，并在磁珠上酶解，然...
樣品：新冠病毒 項目：新冠病毒檢測
產(chǎn)品配置：28臺儀器，0個耗材，0個試劑
The reliable detection and quantitation of low-to-medium polarity persistent organic pollutants in food or environmental samples as required by governmental regulations can be readily made via GC-APCI...
樣品：、 項目：PCBs， PCDDs
產(chǎn)品配置：12臺儀器，0個耗材，0個試劑
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an important tool for high-throughput N-glycan profiling and, upon use of tandem MS, for structure determination.By use of M...
樣品：tissue 項目：質(zhì)譜成像
產(chǎn)品配置：17臺儀器，0個耗材，0個試劑
The peer-reviewed and in-peer-reviewing communications listed below is a non-exhaustive list from the work empowered by MetaboScape? in the years 2019-2020 and many more are to come.MetaboScape is a f...
樣品：、 項目：、
產(chǎn)品配置：17臺儀器，0個耗材，0個試劑
The CCS-aware SpatialOMx? workflow opens new dimensions by combining the molecular and spatial information measuredby MALDI-TIMS Imaging with highly confident 4D-Omics annotations.MetaboScape? 2021b a...
樣品：鼠腦 項目：脂類的質(zhì)譜檢測
產(chǎn)品配置：17臺儀器，0個耗材，0個試劑
The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable...
樣品：Primary human islets 項目：質(zhì)譜
產(chǎn)品配置：29臺儀器，0個耗材，0個試劑
基質(zhì)輔助激光解吸電離（MALDI）成像是DMPK研究的有力工具，它提供了藥物和代謝物的特異性測量，用于早期藥物篩選。timsTOF fleX是布魯克新型的MALDI成像質(zhì)譜系統(tǒng)，憑借ESI/MALDI雙重離子源和把高靈敏的LC-MS/MS PASE...
樣品：大鼠新鮮肝臟和腎臟組織冷凍切片 項目：質(zhì)譜成像
產(chǎn)品配置：20臺儀器，0個耗材，0個試劑
While phospholipids play key roles in lung physiology and pathology, the complex composition and function of the lipidome in the lungs is poorly understood.We applied MALDI mass spectrometry imaging t...
樣品：老鼠肺 項目：質(zhì)譜成像
產(chǎn)品配置：23臺儀器，0個耗材，0個試劑
植物的生長和環(huán)境密切相關(guān)，在環(huán)境污染日益嚴重的當下，植物的生長也不可避免的會引入部分污染物。本實驗運用布魯克磁共振質(zhì)譜（MRMS）研究了污水處理廠附近的楊樹樹葉中污染物含量的變化。MRMS因其擁有超高的質(zhì)量分...
樣品：葉片 項目：質(zhì)譜
產(chǎn)品配置：22臺儀器，0個耗材，0個試劑
在傳統(tǒng)的阿爾茨海默病的病理學研究中，免疫組化（IHC）方法經(jīng)常被用于確定Aβ肽在腦組織中的定位。然而IHC技術(shù)存在著缺陷，因為當同時使用多個表位時，它不能區(qū)分出細微的差別。基于質(zhì)譜的蛋白質(zhì)組學分析作為一種表征...
樣品：腫瘤 項目：質(zhì)譜成像
產(chǎn)品配置：23臺儀器，0個耗材，0個試劑
MALDI Guided SpatialOMx，即基于質(zhì)譜成像定位的空間多組學分析，完美的將MALDI成像技術(shù)和傳統(tǒng)LC-MS/MS組學流程結(jié)合在了一起，它的特點是利用了MALDI成像技術(shù)能在分子原位對生物分子進行定位的特點，在生物組織的內(nèi)...
樣品：腫瘤 項目：質(zhì)譜成像
產(chǎn)品配置：23臺儀器，0個耗材，0個試劑
基于DIA（Data-Independent Acquisition，數(shù)據(jù)非依賴采集）的方法將整個全掃描范圍分為若干個窗口，并循環(huán)地對每個窗口中的所有離子進行碎裂和檢測，這種方法的缺失值少并且定量準確、變異小，有望在大樣本隊列中實...
樣品：HeLa、酵母、大腸桿菌的混合樣本 項目：蛋白
產(chǎn)品配置：11臺儀器，0個耗材，0個試劑
馬鈴薯是一種重要的糧食作物，具有很高的農(nóng)藝和文化價值。為了減少農(nóng)藥的使用和保持馬鈴薯的品質(zhì)，對馬鈴薯抗生物攻擊特性的研究顯得極為迫切。馬鈴薯晚疫病是一種嚴重導致減產(chǎn)的原因，先前文獻中報道，AtACT-AtDTX1...
樣品：馬鈴薯 項目：代謝
產(chǎn)品配置：22臺儀器，0個耗材，0個試劑
Hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) is a versatile technique used to study protein conformational stability, protein-protein and protein-ligand interaction.AbstractHere...
樣品：Subtilisin 項目：Stability Analysis
產(chǎn)品配置：28臺儀器，0個耗材，0個試劑
Known for anti-inflammatory and antioxidant properties, nutraceuticals enriched in Procyanidin-B2 promote hair growth both in vitro and in vivo. However, the metabolic changes associated with the trea...
樣品：murine hair follicles 項目：代謝
產(chǎn)品配置：29臺儀器，0個耗材，0個試劑
Glycoconjugate glycans play vital roles in a wide range of physiological and pathological processes, such as embryogenesis, host-pathogen interactions, inflammation, and tumorigenesis. In the pharmace...
樣品：Glycan 項目：Sequencing
產(chǎn)品配置：29臺儀器，0個耗材，0個試劑
This study utilized multiple mass spectrometry techniques to characterise necroptotic cell death which is mediated by the pseudokinase, mixed lineage kinase domain-like (MLKL). The mass spec data enab...
樣品：membrane 項目：MLKL
產(chǎn)品配置：28臺儀器，0個耗材，0個試劑
The search for new and validated biomarkers is of particular interest in clinical areas like oncology or neurology. As lipids play an important role in many diseases, the area of lipidomics has become...
樣品：lipid 項目：untargeted 4D lipidomics LC-MS/MS workflows
產(chǎn)品配置：10臺儀器，0個耗材，0個試劑
